Kate Flannery appeared as the alcoholic, divorced, single mother Meredith Palmer on the television comedy The Office. Before The Office, she made appearances on The Bernie Mac Show, Boomtown, Curb Your Enthusiasm, and Jimmy Kimmel Live!
In 2008, Flannery was a talent scout on Last Comic Standing with her Office costar Brian Baumgartner, and she appeared with the cast of The Office on Celebrity Family Feud. In 2010 she played Harper's mom on the Disney Channel's Wizards of Waverly Place as Elaine Finkle.
Flannery also appeared as a judge in a 2009 episode of Iron Chef America.
She has also appeared on The Jay Leno Show portraying Wendy in a skit at the time of the burger chain's 40th anniversary.
She was a contestant on 19 episodes of Celebrity Name Game, two episodes of Hollywood Game Night with Jane Lynch. Flannery also appeared on Don't Forget the Lyrics and hosted Standup in Stilettos for two seasons on the TV Guide network.
In 2016, she recurred on ABC's American Housewife as Crossing Guard Sandy, played a janitor in an episode of Brooklyn Nine-Nine, appeared on FOX's New Girl and MTV's Mary Jane, and in 2017 recurred on Cartoon Network's Steven Universe as Barbara "Barb" Miller.
In 2019, Flannery was announced as one of the celebrities to compete on season 28 of Dancing with the Stars. She was partnered with first-time professional Pasha Pashkov.